Experimental models for studying mucociliary clearance
نویسندگان
چکیده
منابع مشابه
Experimental models for studying mucociliary clearance.
Respiratory tract mucus is a viscoelastic gel, the rheological properties of which are determined mainly by its content of mucous glycoproteins and water. The rheology and quantity of mucus, in concert with ciliary factors, are the major determinants of mucociliary clearance. A wide range of animal models for studying the secretion and clearance of mucus are available. Ex vivo models, such as t...
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UNLABELLED Mucociliary transport dysfunctions can impair the quality of life of patients suffering from chronic rhinossinusitis and lead to severe consequences such as alterations in respiratory physiology or even death as in cases of cystic fibrosis and primary ciliary dyskinesia. Therefore, it is crucial to understand the physiology of the mucociliary apparatus and how its components (cilia, ...
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Bronchial secretion forms a periciliary liquid layer and may also give rise to thicker secretion that moves on the tips of the cilia. This latter material as collected at bronchoscopy or coughed up as sputum is a viscoelastic substance behaving in a characteristic way over a wide range of shear rates. The anatomical basis of secretion is described and its control as established by organ culture.
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The saccharin test was carried out in a randomly selected sample of schoolchildren (142 boys and 153 girls, age range 11-14 years) to determine the variability and reproducibility of the test and to assess whether it could be used as a screening test for nasal mucociliary clearance. Nasal mucociliary clearance times were analysed according to clinical history (asthma, rhinitis, asthma with rhin...
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Mucociliary clearance (MCC), a vital key defense mechanism is especially important in the upper airways and sinuses, as it protects the body against noxious inhaled materials [1]. The removal of debris-laden mucus in the sinuses completely depends on MCC, whereas in the lower airways, MCC can be compensated for by other mechanisms like coughing [2]. The nasal mucociliary clearance (NMC) system ...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 1998
ISSN: 0000-0000,0903-1936
DOI: 10.1183/09031936.98.11010222